Smallpox

The first and only human disease to be completely eradicated by vaccination. It killed hundreds of millions of people throughout history.

Discovered in Ancient (known for millennia) by N/A (Edward Jenner created vaccine in 1796)

Face-to-face contact, respiratory droplets, contaminated bedding

Tecovirimat (antiviral); historically no treatment once infected

Vaccination (eradicated in 1980)

Smallpox is the only human disease to ever be completely wiped out by human effort!