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Japanese encephalitis virus
The leading cause of vaccine-preventable encephalitis in Asia and the Western Pacific.
Discovered in 1871 (first described), 1935 (isolated) by Japanese researchers (First isolate: Nakayama strain)
Culex mosquitoes (natural cycle in pigs and wading birds)
Supportive care
Vaccination, mosquito avoidance
Pigs act as 'amplifying hosts', meaning the virus multiplies to very high levels inside them!
Dimerized protein forming a smooth surface
Small membrane protein for assembly
Genetic core packaged by the capsid protein