LOADING 3D BIO-SYSTEMS...
LOADING 3D BIO-SYSTEMS...
Zaire ebolavirus
One of the most deadly viruses known. Ebola causes severe hemorrhagic fever with massive internal bleeding. Its filamentous shape is unique — it can be extremely long, sometimes forming shepherd's crook or circular shapes. The virus is believed to be maintained in fruit bat populations.
Discovered in 1976 by Peter Piot & team (Belgium/Zaire)
Direct contact with blood/body fluids of infected person, contaminated objects, infected animals (fruit bats)
Inmazeb (atoltivimab/maftivimab/odesivimab), Ebanga (ansuvimab), supportive care with IV fluids and electrolytes
rVSV-ZEBOV vaccine (Ervebo), contact tracing, isolation, protective equipment, safe burial practices
Ebola is named after the Ebola River in the Democratic Republic of Congo, near the village where the first recognized outbreak occurred in 1976!
Surface protein forming trimeric spikes — the sole target for antibody-based treatments
Host-derived membrane covering the filamentous nucleocapsid
Most abundant protein — drives the filamentous budding shape
Coats and protects the RNA genome in a helical nucleocapsid
Polymerase cofactor that also suppresses the host immune response
~19,000 nucleotides encoding just 7 structural proteins