Dengue

Dengue is the most common mosquito-borne viral disease, infecting ~390 million people annually. It has 4 serotypes (DENV 1-4). Recovery from one serotype gives lifelong immunity to that type but subsequent infection by a different serotype increases risk of severe dengue (hemorrhagic fever).

Discovered in 1943 by Ren Kimura & Susumu Hotta (Japan)

Aedes aegypti and Aedes albopictus mosquito bites

No specific antiviral — supportive care with fluids, pain relievers (acetaminophen), avoid aspirin/NSAIDs. Severe cases need ICU

Dengvaxia vaccine (limited use), mosquito control (eliminating standing water, insecticides), protective clothing, repellents

Dengue is called 'breakbone fever' because the muscle and joint pain can be so severe that patients feel like their bones are breaking!